Cialis: Voted The Best!

People always want the best and they want them to be cheap also. Compared to other medicine like Levitra and Viagra which are considered as the top contenders of Cialis have been rated on the second and third spot Cialis has become the top Erectile Dysfunction treatment in France, since January 2005, based on the latest market data, surpassing Viagra, the first brand to be launched in this market. It is also doing very well in United Kingdom, Italy, Germany, United States, Canada, Australia, Mexico and Brazil. Not only has Cialis been able to expand the market but it has also captured the market share of Viagra from Pfizer, the first drug to be launched in this market and Levitra from Glaxo-Bayer-Schering Plough. In fact Cialis was the second largest PDE5 inhibitor drug to become available in Europe after Viagra. It is currently promoted in approximately 100 countries including the United States, Australia, Brazil, Mexico, Canada and across Europe and Asia for Erectile Dysfunction.

In terms of physical factor PDE-5(Phosphodiaterase) inhibitors have a significant role to play in Erectile Dysfunction.. These include drugs like Sildenafil (Viagra) and Vardenafil (Levitra). But no drugs have gained the popularity as Cialis did.

It is important to know that how PDE-5 inhibitors work. They work by inhibiting the enzyme phosphodiasterase-5 which is responsible for degrading another enzyme called cGMP (cyclic Guanosine Mono Phosphate) which through a series of reactions is responsible for the synthesis of nitric oxide. Nitric oxide is an important vasodilator responsible for dilation of the blood vessels that supply blood to the penis. Thus, there is an increase in the blood supplied to the penis and this increased blood engorges the penis and leads the formation of an erection through hydraulic pressure.

All PDE-5 inhibitors work in the same way but because they are different molecules, they also have different properties. The body quickly eliminates both Sildenafil and Vardenafil present in Viagra and Levitra respectively. Therefore their action lasts for only 4 hours, while Cialis is absorbed and removed slowly therefore it remains in the body for a longer period of time and Cialis can be taken with a 100% fat meal and there will be no change in time compared to Viagra and Levitra. Therefore its duration of action is 9 times that of other drugs – 36 hours. This ensures that Cialis will act over a massive of 36 hours and any patient on Cialis does not need to have hurried sex, but sex at his or his partner’s mood.