Cialis: Drug Reactions

Like all medicines Cialis also interact with several medicines as the name list could be longer.

Patients are suggested to check all the active ingredients and combinations of each medicine they are taking and discuss in detail about them with their healthcare providers.

The following sections explain in detail the following interactions that can occur when Cialis is combined with any of the drugs listed here

Alcohol

Taking Cialis pill with a significant amount of alcohol can cause a fast heart rate (tachycardia), low blood pressure (hypotension), dizziness, and headache.

CYP 3A4 Inhibitors

Cialis is broken down ("metabolized") by certain enzymes in the liver known as CYP 3A4 enzymes. Certain other medications (known as CYP 3A4 inhibitors) decrease the activity of the enzymes, thereby increasing the level of Cialis in the blood. This may lead to serious side effects in some cases. Check with your healthcare provider before taking Cialis with a CYP 3A4 inhibitor.

Alpha Blockers

Combing Cialis with alpha blockers like Phenoxybenzamine, Prazosin, Alfuzosin can cause low pressure (including dangerously low blood pressure in some cases). Check with your healthcare provider before taking these drugs together.

Blood Pressure Medications

Taking Cialis with a high blood pressure medication such as Isosorbide mononitrate is likely may cause your blood pressure to decrease too much. Check with your healthcare provider before combining these medicines.

Nitrates

If you are taking nitrates, you should not use Cialis. Even if you use a nitrate infrequently, you should not take Cialis, since you cannot predict when you will need to take the nitrate.

Other Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors)

Cialis is a PDE5 inhibitor and should not be combined with other such medications, even if they are not used to treat erectile dysfunction.

Theophylline

Taking theophylline and Cialis together may cause a slight increase in heart rate. Your healthcare provider may choose to make necessary dosing adjustments if you have to take these drugs together.

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.